One Helix is a building designed by UNS and developed by Breakthrough Properties for the biopharmaceutical company AstraZeneca. It demonstrates how ambitious sustainability goals can be translated into a commercially viable, high-performance workplace, accommodating life-science laboratories, offices, and support facilities.

Designed to exceed Nearly Zero-Energy Building (NZEB) standards, the project embeds energy-efficiency principles into its massing, façades, roof, and material selection. It also prioritises flexibility, comfort, and indoor environmental quality, avoiding an overly clinical atmosphere while creating supportive, calm, comfortable, and functional spaces.

Located next to Amsterdam University Medical Center (Amsterdam UMC), One Helix combines the technical demands of an advanced laboratory facility with a comprehensive whole-life carbon management strategy. Conceived to accommodate both current and future research needs, it brings together laboratories, offices, meeting rooms, storage areas, support services, and technical infrastructure.

For the development of the One Helix laboratory, the practice UNS focused on designing —in conjunction with the site and building volume— a structure that would reduce the carbon footprint by at least half compared to similar buildings in the Netherlands. To achieve this, a life cycle assessment was conducted, utilizing circular and biophilic materials wherever possible. In addition, a solar shading system and a combination of passive cooling systems were incorporated, enabling the building to achieve BREEAM Outstanding and NZEB accreditation.

"This new headquarters building will reinforce AstraZeneca's ongoing efforts to pioneer T-cell receptor therapies in a healthy and collaborative work environment that meets, and even exceeds, the highest sustainability standards. We have also integrated biophilic design elements and natural materials to complement the technical system design and create healthy work and leisure spaces for all AstraZeneca employees."

Ben van Berkel, Founder and Principal Architect of UNS.

One Helix by UNS. Photograph by Seth Carnill.

One Helix by UNS. Photograph by Seth Carnill.

This was achieved through the careful optimization of construction materials, concluding that a hybrid structure with low-carbon concrete and steel would outperform a timber structure. One Helix features a lightweight, demountable structure, as well as reduced cement consumption thanks to the reuse of urban materials. Its simple design contributed to reducing environmental impact and facilitated its subsequent adaptation with minimal waste, also allowing for future reuse. The building demonstrates that it is possible to reduce material consumption and carbon emissions within conventional construction systems.

Other measures employed to support the project's energy objectives include solar panels integrated into the facade, high-efficiency ventilation systems that recover energy, heat exchange systems, roofs that help regulate the interior temperature naturally, and underground systems for thermal energy storage. These construction systems, along with a green roof and water retention, reduce the urban heat island effect, promote biodiversity, and improve climate resilience. The shared electric mobility and charging infrastructure in the basement further reinforces the project's low-carbon strategy.

One Helix by UNS. Photograph by Seth Carnill.

One Helix by UNS. Photograph by Seth Carnill.

The facade design emerged from both performance and aesthetic requirements. Initial facade studies focused on reducing heat load, improving natural lighting, and providing workplace comfort, resulting in a clear concept where the solar shading strategy was fully integrated into the architecture. One Helix's solar shading elements, developed with i-Mesh, were designed considering orientation, solar heat gain, and wind load, and tested through daylight and solar studies, as well as scale models, to ensure suitable conditions for both laboratories and offices.

The screens were formed as rigid, resin-impregnated elements made from basalt fiber. Their custom pattern was calibrated to balance transparency with solar shading and meet stringent performance tolerances. They were also designed to maintain stability in strong winds and provide a consistent environmental response.

One Helix by UNS. Photograph by Seth Carnill.

One Helix by UNS. Photograph by Seth Carnill.

The color palette was derived from an analysis of Impressionist landscape painting, identifying the tones that are most frequently repeated in representations of the natural world: tiles that reference natural stone, wood used throughout the building, a living wall at the entrance, and textiles with prints inspired by natural forms.

The interior design, linked to the architecture, seeks, as with the exterior facade, to balance environmental performance with commercial realities, ensuring that sustainable materials are economically adapted to the budget, exploring alternatives, and guaranteeing circularity and reducing the building's impact.

In this way, One Helix becomes the first project with a studio approach for subsequent workspaces.

More information

Label
Architects
Text

UNS. Lead architects.- Ben van Berkel.

+ + copy Created with Sketch.
- + copy Created with Sketch.
Label
Project team
Text

Ben van Berkel, Arjan Dingsté with René Toet and Ilaria Ronchi, Reinier Kok, Albert Gnodde, Borja Fernández Flórez, Tom Minderhoud, Milou van Min, Regiane Fernandes and Evelina Ilina.

+ + copy Created with Sketch.
- + copy Created with Sketch.
Label
Collaborators
Text

Project Management.- Savills Building & Project Consultancy.
Structural Engineer.- Aronsohn.
MEP Engineer.- Buro Happold.
Sustainability Consultant.- Build 2 Live.
BENG/NZEB Consultant.- Ingenieursbureau Linssen.
Building Physics, MPG & FLS.- Cauberg Huygen.
Facade shading elements.- i-Mesh.
Cost Consultants.- Bremen Bouwadviseurs and Linesight.

+ + copy Created with Sketch.
- + copy Created with Sketch.
Label
Client
Text

Breakthrough Properties.

+ + copy Created with Sketch.
- + copy Created with Sketch.
Label
Area
Text

6.515 sqm.

+ + copy Created with Sketch.
- + copy Created with Sketch.
Label
Dates
Text

Date of completion.- 2025.

+ + copy Created with Sketch.
- + copy Created with Sketch.
Label
Location
Text

Amsterdam, Netherlands.

+ + copy Created with Sketch.
- + copy Created with Sketch.
Label
Photography
+ + copy Created with Sketch.
- + copy Created with Sketch.

UNS is an architecture studio founded by Ben van Berkel and Caroline Bos in 1999, headquartered in Amsterdam, Netherlands, with additional international offices in Shanghai, Hong Kong, Dubai, Frankfurt, Melbourne and Austin.  

Ben van Berkel, Founder and Principal Architect of UNS, is renowned for his cutting-edge design, dedication to sustainability, and deep understanding of the impact the built environment has on health and wellbeing.  His unconventional approach, which investigates the interconnections between culture and commerce, consistently breaks new creative ground and works to solve real world problems.  He brings creative and visionary thinking to an expanding set of expertises within the fields of health, sustainability, technology and economics, delivering evermore value to clients and partners.

After studying at the Rietveld Academy in Amsterdam and the Architectural Association in London, in 1988 he and Caroline Bos founded the Van Berkel & Bos Architectuurbureau, realising iconic projects like the Erasmus Bridge and the Möbius House. In 1999, they established UNS, a global network specialising in design and consulting.  Pivotal projects currently include the Lyric Theatre Complex in Hong Kong, the ChamartÍn Station masterplan in Madrid, FOUR, a large-scale mixed-use project in Frankfurt, the Wasl Tower in Dubai and the Austin Light Rail in Texas.

Committed to education, Ben has held the Kenzo Tange Visiting Professor’s Chair at Harvard GSD where he continues to run a studio on health. He also serves as MArch Thesis Chair and sits on the Advisory Board at IE School of Architecture and Design in Madrid.

Caroline Bos brings a deep understanding of urban and regional planning to her role as Co-Founder and Principal Urban Planner of UNS, where she focuses on creating vibrant, sustainable urban ecosystems. With a background in Art History and Urban Planning, Caroline’s work bridges theory and practice, shaping cities where people, nature, infrastructure, and culture intersect. Caroline’s approach to urban design is human-centered and forward-thinking, addressing social, economic, and environmental challenges to create cities that adapt, thrive, and inspire. Through masterplans, urban frameworks, and identity-driven spaces, she ensures that cities honour their past while preparing for the future, all while supporting the people that live in them.

Alongside her practice, Caroline has taught at institutions such as Princeton University and the University of Melbourne, where she emphasises the integration of virtual and material organisation in architectural and urban works.

Read more
Published on: July 17, 2026
Cite:
metalocus, SARA GENT, MARÍA MÍNGUEZ
"A new formula for the laboratories of the future. One Helix by UNS" METALOCUS. Accessed
<https://www.metalocus.es/en/news/new-formula-laboratories-future-one-helix-uns> ISSN 1139-6415
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...
Loading content ...